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Immunovet® for maintaining the health of liver cells

In a recent study, Immunovet® was proved to be effective in protecting the liver against bacterial toxin damage in liver cells, isolated from rats.

Liver is the central organ of metabolism and detoxification in both human and animal body. After food consumption, nutritional substances (including potentially toxic compounds) enter the liver. After absorption from the intestines these substances undergo a variety of chemical transformations before they enter the central circulation, which transports them to every cells in the body. In the case of toxic substances, the main purpose of the detoxification reactions are to eliminate these dangerous substances before they could reach vital organs. It follows, that the liver is the most exposed organ to toxic compounds and plays an essential protective role against the toxic substances. During liver damage an oxidative stress occurs, which can be reduced with antioxidant-effect liver protectors, like Immunovet®.

In a recent study, Immunovet® was examined on rat liver cells at the University of Veterinary Medicine Budapest. These cells were treated with toxins from Salmonella Typhimurium, which often causes gastrointestinal infections in our pets and animals. In addition to the toxin, some of the cells received Immunovet® and two other groups received well-known liver-protector drugs. Immunovet® was examined for its ability to reduce the oxidative stress caused by the toxin in liver cells, because it has already been shown to be an antioxidant in other cell types.

Experiments have shown, that Immunovet® was asble to reduce bacterial toxin-induced oxidative stress in liver cells significantly:

  • Resulted lower production of free radicals
  • The amounts of molecules indicating cell-membrane damage has decreased

The effects of Immunovet® were similar to the two active substances they used as a comparison partner. In conclusion, Immunovet® can be used effectively to maintain the health of liver cells.

The research was made in the University of Veterinary Medicine Budapest, Department of Pharmacology and Toxicology and the Division of Biochemistry

(Source: Gábor Mátis, Máté Mackei, Kata Oláhné Orbán, Zsuzsaanna Neogrády, Ákos Jerzsele: Effect of fermented wheat-germ extract (Immunovet®) on the redox homeostasis of liver. In vitro studies in rat primary liver cell culture. – University of Veterinary Medicine Budapest - Department of Pharmacology and Toxicology, Division of Biochemistry)