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Immunovet® protective effect against mold toxins

A recent study at the University of Veterinary Medicine Budapest examined the protective effect of Immunovet® against mold toxins.

Mycotoxins are the toxic compounds produced by various molds. These toxins can occur in cereal seeds, if these funguses infect the plants in the field. The infection mostly occurs in warm, humid weather periods, when the 50-60% of the plants can be infected. Toxins in the forage and nutrition can harm our pets and animals many ways:

  • Mycotoxin can cause apoptosis in the immune system’s cells
  • Causes oxidative stress
  • Have a negative impact on the integrity of the intestinal epithelium

A recent study at the University of Veterinary Medicine Budapest investigated the protective effect of Immunovet® against various mold mycotoxins. They treated intestinal epithelial cells with DON and T-2 toxins and with the combination of these. These are the most common contaminator mold mycotoxins on fields. Immunovet® effects on cells has been analyzed individually and in combination with toxins as well. Cell viability, cell layer integrity, and oxidative stress signaling molecule’s level were measured to determine the damage of cells and potential protective effects of Immunovet®.

Results:

Immunovet® (used alone) enhanced cell viability and cell layer integrity. In combination with mycotoxins, Immunovet® showed protective effects against toxin-induced oxidative stress and loss of cell integrity. Based on the results, Immunovet® can contribute to the maintenance of healthy cellular function in case of mycotoxin contamination.

Research was made at the University of Veterinary Medicine Budapest, Department of Pharmacology and Toxicology.

(Source: Dorottya Prokoly, Judit Pomothy, Erzsébet Pásztiné Gere, 2019: The effect of fermented wheat-germ extract (Immunovet®) on porcine intestinal cells induced by fusarium toxins.)